Medicine shortage crushes Aussie ICU capacity

Well oh dear, at Domain:

Hospitals are struggling to source drugs including propofol and cisatracurium, used to sedate patients before they are intubated, which are needed to take ICUs to full capacity if there is a second wave of coronavirus infections after restrictions are lifted.

“As part of Australia’s COVID-19 response, hospitals are still on standby for a patient surge and remain concerned at the number of delayed or not-supplied orders from suppliers,” Society of Hospital Pharmacy Australia chief executive Kristin Michaels said.

The society, which has been monitoring stock levels in recent weeks, found 18 per cent of the 60 hospitals it surveyed in early May did not have enough propofol to manage ventilated patients at full capacity for a single day.

On average, the surveyed hospitals had enough propofol and neuromuscular blockers to run just 10 per cent of the additional ventilators sourced for a COVID-19 surge, the survey found.

The entire build-out is a joke then.

It’s not easy fix, either. We don’t make these drugs. In fact, we make almost no drugs at all, via The Institute of Integrated Economics:

Australia imports 90 per cent of its medicines, with around one-third of Australians reliant on daily prescriptions. However, the country is at the tail end of lengthy global supply chains with what the report calls ‘single points of failure’.

An infamous example was the nationwide shortage of EpiPen Jrs, used to treat anaphylactic reactions in children. Manufacturing issues and quality failures in the supply chain caused Australian supplies to run out in December 2019, prompting the Therapeutic Goods Administration (TGA) to advise Australians to use out-of-date or contaminated EpiPens. Supplies will only resume ‘before the end of the year’.

The problem is not unique to Australia: a public hearing held by the US government heard witnesses warn of a critical dependence on China for medicine supplies. Almost 90 per cent of American pharmaceuticals are generic medicines largely imported from China and India, with China responsible for ‘deliberate market manipulation’ that has reduced America’s indigenous drug manufacturing capability.

The report makes clear that medical supply chains are opaque and difficult to analyse in both the US and Australia.

“Significant issue is the apparent lack of an entity in the US Federal Government that is accountable for knowing who controls the US medicine supply,” the report argues. “According to Michael Wessel, a Commissioner on the US Government’s US-China Economic and Security Review Commission, the US simply does not know enough about China’s pharmaceutical sector, yet most APIs are imported from China or India, with India, in turn, actually sourcing a large number of inputs from China.

“This is particularly of concern given that US imports 95 per cent of ibuprofen and between 40 and 45 per cent of penicillin supplies from China.”

The report notes Australia’s similarly weak indigenous medicines manufacturing capability.

“Australia has extremely limited and diminishing manufacturing capacity across all sectors of products apart from vaccine manufacture,” the report argues. “There are some smaller industries with capacity for niche markets; however, government price regulation around the Pharmaceutical Benefits Scheme has forced the large majority of off-patent product manufacturing, where the vast majority of life-saving medicines sit, off-shore.

“Australia has almost no capacity to manufacture any active pharmaceutical product for most of the products listed on World Health Organisation’s list of Essential Medicines.”

Although Australian self-sufficiency in drug manufacture is not wholly practical, the report argues that the current bipartisan political drive for a sovereign defence industrial capability could serve as a model for similarly sovereign medicines capability: “We need to have a robust analysis of our medicine supply chains and the Government needs to address any shortfalls in our national resilience before a crisis occurs.”

I’m sure a bit of tiger’s dong will do the trick. The full report is here.

David Llewellyn-Smith
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    • Bingo, Australia could easily produce all of its own medicines if the government really wanted too. Although a few ‘free trade’ deals might get torn up in the process.

  1. I’m sure a bit of tiger’s dong will do the trick.
    Ah finally I know what the metaphor “Grabbing the Tiger by the Tail” .is suppose to mean

  2. Glorious Taiwan

    The Chinese are already punishing us for merely asking for an independent inquiry into a global pandemic that has killed hundreds of thousands and destroyed the global economy. All so that we can learn from the pandemic to avoid it happening in the future.

    In 5 years it will be if you don’t support our annexation of Taiwan we will send the Chinese fleet your way.

  3. Apparently NZ is on the edge of no propofol. There have been talks of arranging emergency flights to try to secure some.

    Elective surgery is not returning any time soon without it. It’s about as essential a drug as you could think of.

  4. We have some pharma factories.

    Surely with known processes and qualified staff it’s not too difficult to get them to produce the essentials?

      • Maybe the organisation for strip searching children, otherwise known as the NSW Police, could come to a quid-pro-quo with the Ibrahim’s. They share the names of a few local chemists and the kiddy searchers will stop raiding his house every few months and taking photos, which then end up in the DT.

  5. matthewMEMBER

    Must say everyone has been saying that our hospitals are well prepared to cope with a second wave and I have been saying to myself how so?This is not the only medical problem we will face come a second wave

  6. tripsterMEMBER

    Doesn’t this show the utter pointlessness of current defence strategy? Why spend $50 billion on submarines if, in a conflict with China, we’d be crippled by not having even basic medicines within days?

  7. even those we do supposedly make seem to be difficult to come by. I take 100mg thyroxine. Doc tells me made in Aus. Aspen made an release saying due to unprecedented demand (read hoarding). I struggle to see this as most of us get in boxes that are about 6mnths worth and have to refrigerate. even then don’t last much longer so not able to stock huuuuge. I am having to go to pharmacy on a bi-weekly basis to get 2 strips at a time. they keep telling me there will be more stock and each time- aah there seems to be a hold up in restocking. I am strongly of the opinion that Aspen can’t get the raw ingredients read chemicals to make it and many other prescription products (pharmasists tell me there are loads of prescription products being rationed) …

    • be interested as to whether only in Brighton/ Hampton (bayside) vic or if any have had these issues elsewhere. from Aspen announcment seems to be national